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Microfluidic Device for Transport and Observation of Single Cells

[+] Author Affiliations
Saeed A. Merza, Jonathan D. Posner, Yasser H. Anis, A. Cody Young, Roger H. Johnson, Deirdre R. Meldrum

Arizona State University, Tempe, AZ

Paper No. IMECE2009-13019, pp. 2213-2220; 8 pages
  • ASME 2009 International Mechanical Engineering Congress and Exposition
  • Volume 9: Heat Transfer, Fluid Flows, and Thermal Systems, Parts A, B and C
  • Lake Buena Vista, Florida, USA, November 13–19, 2009
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4382-6 | eISBN: 978-0-7918-3863-1
  • Copyright © 2009 by ASME


A fluidic device capable of aspirating microparticles in aqueous medium and transporting them under controlled conditions to a chosen destination is reported. The device is fabricated through repeated stacking of aligned, laser cut acrylic, mylar and adhesive layers. The rectangular cross-section of the primary flow chamber within the device follows a specific mathematical function to achieve a desired velocity profile for improved particle tracking. Flow is controlled into and out of the chamber by three-way solenoid valves to allow changes in flow direction and to minimize capacitance in the fluidic circuit. The valves are connected to syringe pumps which generate positive and negative pressures within the device. Aspirated microparticles can be accurately transported by controlling the ON/OFF state of the solenoid valves. Computational fluid dynamic (CFD ) models are employed to compare the theoretically derived velocity field and pressure distributions with analytical solutions and observations. Processed imagery showed the positions versus time of microparticle flowing through the chamber channel.

Copyright © 2009 by ASME



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