0

Full Content is available to subscribers

Subscribe/Learn More  >

Microfluidic Device for Transport and Observation of Single Cells

[+] Author Affiliations
Saeed A. Merza, Jonathan D. Posner, Yasser H. Anis, A. Cody Young, Roger H. Johnson, Deirdre R. Meldrum

Arizona State University, Tempe, AZ

Paper No. IMECE2009-13019, pp. 2213-2220; 8 pages
doi:10.1115/IMECE2009-13019
From:
  • ASME 2009 International Mechanical Engineering Congress and Exposition
  • Volume 9: Heat Transfer, Fluid Flows, and Thermal Systems, Parts A, B and C
  • Lake Buena Vista, Florida, USA, November 13–19, 2009
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4382-6 | eISBN: 978-0-7918-3863-1
  • Copyright © 2009 by ASME

abstract

A fluidic device capable of aspirating microparticles in aqueous medium and transporting them under controlled conditions to a chosen destination is reported. The device is fabricated through repeated stacking of aligned, laser cut acrylic, mylar and adhesive layers. The rectangular cross-section of the primary flow chamber within the device follows a specific mathematical function to achieve a desired velocity profile for improved particle tracking. Flow is controlled into and out of the chamber by three-way solenoid valves to allow changes in flow direction and to minimize capacitance in the fluidic circuit. The valves are connected to syringe pumps which generate positive and negative pressures within the device. Aspirated microparticles can be accurately transported by controlling the ON/OFF state of the solenoid valves. Computational fluid dynamic (CFD ) models are employed to compare the theoretically derived velocity field and pressure distributions with analytical solutions and observations. Processed imagery showed the positions versus time of microparticle flowing through the chamber channel.

Copyright © 2009 by ASME

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In