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Characterization of Aortic Root Compliance at Different Heights

[+] Author Affiliations
Eric M. Sirois, Tsuicheng Chiu, Martin Fox, Wei Sun

University of Connecticut, Storrs, CT

Paper No. IMECE2008-67824, pp. 471-472; 2 pages
  • ASME 2008 International Mechanical Engineering Congress and Exposition
  • Volume 2: Biomedical and Biotechnology Engineering
  • Boston, Massachusetts, USA, October 31–November 6, 2008
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4863-0 | eISBN: 978-0-7918-3840-2
  • Copyright © 2008 by ASME


Aortic valve stenosis is a significant cause of morbidity and mortality [1]. Currently, the preferred treatment of severe aortic stenosis is aortic valve replacement, which carries a significant risk for patients with comorbidities [2]. Recently, percutaneous aortic valve (PHV) replacement represents an endovascular alternative to conventional open heart surgery without the need for sternotomy, aortotomy, or cardiopulmonary bypass [3]. However, there are significant serious adverse events associated with the percutaneous procedure, such as myocardial infarction, peripheral embolism, injury to the aorta, perivalvular leak and access site injury [3–5]. Furthermore, long-term durability and safety of these valves need to be evaluated and studied carefully. We hypothesize that the device (dys)function could be more accurately predicted if a better understanding of the biomechanical interaction between the native aortic valve/root and the PHV were available. In this study, our objective is to characterize the mechanical properties of the aortic root such that its interaction with the PHV device can be quantified.

Copyright © 2008 by ASME



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