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Biomolecular Activity Switch: An Application of Metallic Nanoparticle Plasmon Resonance and Femtosecond Pulsed Lasers

[+] Author Affiliations
Joshua Alper, Kimberly Hamad-Schifferli

Massachusetts Institute of Technology, Cambridge, MA

Paper No. IMECE2008-68104, pp. 255-257; 3 pages
  • ASME 2008 International Mechanical Engineering Congress and Exposition
  • Volume 2: Biomedical and Biotechnology Engineering
  • Boston, Massachusetts, USA, October 31–November 6, 2008
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4863-0 | eISBN: 978-0-7918-3840-2
  • Copyright © 2008 by ASME


With an increased effort within the engineering community to design molecular machines, it has become clear that a specific, external control method is required. Here we propose a simple mechanism for a molecular switch involving conjugating a molecule within the machinery to a gold nanorod. Then actuate that machinery’s active state by affecting a change in the conjugated molecule. We demonstrate the feasibility of the method using a fluorescent probe, and we report on progress we have made toward demonstrating it with a protein.

Copyright © 2008 by ASME



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