0

Full Content is available to subscribers

Subscribe/Learn More  >

Fabrication of Magnetic Nanocomposite Spheres for Targeted Drug Delivery

[+] Author Affiliations
R. Asmatulu, A. Fakhari, H. L. Wamocha, H. H. Hamdeh, J. C. Ho

Wichita State University, Wichita, KS

Paper No. IMECE2008-69095, pp. 195-198; 4 pages
doi:10.1115/IMECE2008-69095
From:
  • ASME 2008 International Mechanical Engineering Congress and Exposition
  • Volume 2: Biomedical and Biotechnology Engineering
  • Boston, Massachusetts, USA, October 31–November 6, 2008
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4863-0 | eISBN: 978-0-7918-3840-2
  • Copyright © 2008 by ASME

abstract

Biodegradable magnetic nanocomposite spheres were synthesized using magnetite nanoparticles and poly (D,L-lactide-co-glycolide) (PLGA) for the purpose of magnetic targeted drug delivery. Magnetic nanoparticles (∼10 nm) were prepared by a chemical co-precipitation of ferric and ferrous chloride salts in the presence of a strong basic solution (ammonium hydroxide). An oil-in-oil emulsion/solvent evaporation technique was conducted at 7000 rpm and 1.5–2 hrs agitation for the synthesis of nanocomposite spheres. Prior to the experiment, PLGA was dissolved in acetonitrile (phase I), and then added drop-wise into the viscous paraffin oil combined with Span 80 (phase II). The effect of magnetic particle concentrations (0%, 5%, 10%, 20% and 30%) on nanocomposite particles, the particle distribution and morphology were investigated using dynamic laser light scattering (DLLS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The test results proved that the magnetic nanocomposite spheres were in the range of 200 nm to 1.03 μm.

Copyright © 2008 by ASME

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In