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Fabrication of Magnetic Nanocomposite Spheres for Targeted Drug Delivery

[+] Author Affiliations
R. Asmatulu, A. Fakhari, H. L. Wamocha, H. H. Hamdeh, J. C. Ho

Wichita State University, Wichita, KS

Paper No. IMECE2008-69095, pp. 195-198; 4 pages
  • ASME 2008 International Mechanical Engineering Congress and Exposition
  • Volume 2: Biomedical and Biotechnology Engineering
  • Boston, Massachusetts, USA, October 31–November 6, 2008
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4863-0 | eISBN: 978-0-7918-3840-2
  • Copyright © 2008 by ASME


Biodegradable magnetic nanocomposite spheres were synthesized using magnetite nanoparticles and poly (D,L-lactide-co-glycolide) (PLGA) for the purpose of magnetic targeted drug delivery. Magnetic nanoparticles (∼10 nm) were prepared by a chemical co-precipitation of ferric and ferrous chloride salts in the presence of a strong basic solution (ammonium hydroxide). An oil-in-oil emulsion/solvent evaporation technique was conducted at 7000 rpm and 1.5–2 hrs agitation for the synthesis of nanocomposite spheres. Prior to the experiment, PLGA was dissolved in acetonitrile (phase I), and then added drop-wise into the viscous paraffin oil combined with Span 80 (phase II). The effect of magnetic particle concentrations (0%, 5%, 10%, 20% and 30%) on nanocomposite particles, the particle distribution and morphology were investigated using dynamic laser light scattering (DLLS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The test results proved that the magnetic nanocomposite spheres were in the range of 200 nm to 1.03 μm.

Copyright © 2008 by ASME



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