Full Content is available to subscribers

Subscribe/Learn More  >

Engineering as a Tool in Assisted Reproduction: An Investigation Using Mathematical Modelling of Oxygen Transport in the Ovarian Follicle

[+] Author Affiliations
Gabe P. Redding, John E. Bronlund

Massey University, Palmerston North, New Zealand

Paper No. IMECE2008-66519, pp. 67-75; 9 pages
  • ASME 2008 International Mechanical Engineering Congress and Exposition
  • Volume 2: Biomedical and Biotechnology Engineering
  • Boston, Massachusetts, USA, October 31–November 6, 2008
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4863-0 | eISBN: 978-0-7918-3840-2
  • Copyright © 2008 by ASME


The key objective of any Assisted Reproductive Technology (ART) is to provide infertile couples with the maximal chance of producing healthy offspring and there is a large body of research within this field directed toward this objective. However, despite this volume of research attention, the success rates of many procedures such as In-Vitro fertilization (IVF) have improved little since their inception. Engineering principles have not been widely applied to ART and, as a result, it appears that there is great potential for engineering to make a contribution to this field. The objectives of this work were to demonstrate the usefulness of engineering principles in this field via the example of modelling oxygen transport in the preovulatory human ovarian follicle. The results show mathematical relationships between follicular fluid dissolved oxygen levels, follicular vascularity and the developmental potential of the oocyte can be described. These relationships are shown to be consistent with findings reported in the literature. Significant results include the emergence of cut off levels of both follicular vascularity and follicle size below which all eggs will be starved of oxygen. Based on current model parameters these cut off levels are predicted to range from 22–40% and 3.5–4.3 ml (19.0–20.3 mm follicle diameter) for follicle vascularity and volume respectively. These results serve to highlight the potential contribution of engineering in general to ART. The implications of these findings are also discussed as are future improvements for modelling mass transport in the ovarian follicle.

Copyright © 2008 by ASME



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In