Full Content is available to subscribers

Subscribe/Learn More  >

Utilization of Simple Scaling Laws for Modulating Tip-Sample Interaction Forces in Aqueous Environment AFM Characterization: Application to the Self-Assembly of Protein Polymers

[+] Author Affiliations
Santiago D. Solares, Jonathan Chang, Joonil Seog, Adam U. Kareem

University of Maryland at College Park, College Park, MD

Paper No. DETC2011-47199, pp. 469-473; 5 pages
  • ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference
  • Volume 7: 5th International Conference on Micro- and Nanosystems; 8th International Conference on Design and Design Education; 21st Reliability, Stress Analysis, and Failure Prevention Conference
  • Washington, DC, USA, August 28–31, 2011
  • Conference Sponsors: Design Engineering Division and Computers and Information in Engineering Division
  • ISBN: 978-0-7918-5484-6
  • Copyright © 2011 by ASME


We have recently reported on experimental observations of silk-elastin-like protein polymers (SELPs) that self-assembled into 1-dimensional nanofibers on mica surfaces upon application of a mechanical stimulus with atomic force microscopy (AFM) in water. SELPs are genetically engineered block co-polymers made of silk-like blocks (Gly-Ala-Gly-Ala-Gly-Ser) from Bombyx mori (silkworm) and elastin-like blocks (Gly-Val-Gly-Val-Pro) from mammalian elastin. The experiment consisted of adsorbing the protein polymer onto a freshly cleaved mica surface, followed by AFM characterization under different sets of imaging parameters, each of which led to different nanofiber coverage rates. In order to gain further understanding of the factors governing the self-assembly process, we utilized multimodal AFM simulation to formulate and guide the implementation of a suitable force modulation strategy, which allowed us to observe trends of the surface coverage rate as a function of the applied peak forces. The simulations suggest that a nearly linear control of the peak tapping forces can be achieved by following simple scaling laws based on the harmonic oscillator model.

Copyright © 2011 by ASME



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In