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High Throughput Nanofluidic Architectures for Nanoparticle Separation

[+] Author Affiliations
Anmiv S. Prabhu, Kevin Freedman, Rafael Mulero, Min Jun Kim

Drexel University, Philadelphia, PA

Talukder Zaki Jubery, Prashanta Dutta

Washington State University, Pullman, WA

Paper No. IMECE2009-10649, pp. 1497-1503; 7 pages
doi:10.1115/IMECE2009-10649
From:
  • ASME 2009 International Mechanical Engineering Congress and Exposition
  • Volume 9: Heat Transfer, Fluid Flows, and Thermal Systems, Parts A, B and C
  • Lake Buena Vista, Florida, USA, November 13–19, 2009
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4382-6 | eISBN: 978-0-7918-3863-1
  • Copyright © 2009 by ASME

abstract

High blood cholesterol levels and associated complications are a major health concern the world over and current techniques to deal with this, especially low density lipoprotein (LDL) apheresis, have significant room for improvement. We had previously reported a proof of concept technique that relies on silicon nitride based solid state nanopores to separate high density lipoprotein (HDL) like particles from LDL like particles. A mathematical model to describe the setup is reported. This model revealed that charge density of the pore surface was critical in determining the efficiency of separation. Accordingly we chemically modified our nanopores with (3-aminopropyl)-triethoxysilane (APTES) to achieve more efficient, high throughput particle separation. Such a technique could make it possible to develop safe and affordable LDL apheresis devices in the future.

Copyright © 2009 by ASME

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