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Spherical Modeling and Nonlinear Model Predictive Control of Electroporation

[+] Author Affiliations
Jingang Yi, Jianbo Li, Hao Lin

Rutgers, The State University of New Jersey, Piscataway, NJ

Paper No. DSCC2011-5984, pp. 545-552; 8 pages
doi:10.1115/DSCC2011-5984
From:
  • ASME 2011 Dynamic Systems and Control Conference and Bath/ASME Symposium on Fluid Power and Motion Control
  • ASME 2011 Dynamic Systems and Control Conference and Bath/ASME Symposium on Fluid Power and Motion Control, Volume 2
  • Arlington, Virginia, USA, October 31–November 2, 2011
  • Conference Sponsors: Dynamic Systems and Control Division
  • ISBN: 978-0-7918-5476-1
  • Copyright © 2011 by ASME

abstract

Electroporation is an effective means to deliver molecules into the cellular cytoplasm, and has been widely applied in both biological research and clinical applications. The process however suffers from low viability and efficiency. In this work, we present a multi-pulse feedback control scheme for enhancing viability and efficiency of electroporation process. We first present a spherical model for cell transmembrane potential (TMP) dynamics to describe the spatial distribution of electric potential on cell membrane. Then we analyze the models and discuss the bifurcation property of the system. Based on the dynamic models, we design a nonlinear model predictive controller (NMPC) to track pore size profiles in electroporation. We demonstrate that by using NMPC, the pore size can be precisely regulated to targeted values for drug delivery applications. The control design is illustrated through simulation examples.

Copyright © 2011 by ASME

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