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Evaluating Nucleus Effect on the Cell Mechanical Behavior

[+] Author Affiliations
Guoxin Cao, Namas Chandra

University of Nebraska Lincoln, Lincoln, NE

Paper No. IMECE2009-12837, pp. 503-504; 2 pages
doi:10.1115/IMECE2009-12837
From:
  • ASME 2009 International Mechanical Engineering Congress and Exposition
  • Volume 2: Biomedical and Biotechnology Engineering
  • Lake Buena Vista, Florida, USA, November 13–19, 2009
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4375-8 | eISBN: 978-0-7918-3863-1
  • Copyright © 2009 by ASME

abstract

The mechanical behaviors of cells are closely related to cell biological functions, which are typically studied using the continuum and homogeneous cell model. The associated parameters in these models are determined from experiments, e.g. AFM indentation. In these studies, the effect of nucleus is not explicit studied and thus not clear. In the current study, the indentation behavior of cell with an explicit nucleus is investigated using numerical simulations.

Copyright © 2009 by ASME

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