0

Full Content is available to subscribers

Subscribe/Learn More  >

Quantitative Images of Elastic Modulus Using Tissue Dynamics in the Region of Impulsive Acoustic Radiation Force Excitation

[+] Author Affiliations
Mark L. Palmeri, David Xu, Michael Wang, Kathryn Nightingale

Duke University, Durham, NC

Paper No. IMECE2009-12695, pp. 487-491; 5 pages
doi:10.1115/IMECE2009-12695
From:
  • ASME 2009 International Mechanical Engineering Congress and Exposition
  • Volume 2: Biomedical and Biotechnology Engineering
  • Lake Buena Vista, Florida, USA, November 13–19, 2009
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4375-8 | eISBN: 978-0-7918-3863-1
  • Copyright © 2009 by ASME

abstract

Focused, impulsive, acoustic radiation force excitations can generate shear waves with microns of displacement in tissue. The speed of shear wave propagation is directly related to the tissue’s shear modulus, which can be correlated with tissue pathology to diagnose disease and to follow disease progression. Shear wave speed reconstruction has conventionally been measured over spatial domains that are spatially-offset from the region of excitation (ROE). While these methods are very robust in clinical studies characterizing large, homogeneous organs, their spatial resolution can be limited when generating quantitative images of shear elasticity. The ROETTP algorithm measures time-to-peak (TTP) displacements along the axis-of-symmetry in the ROE of an impulsive acoustic radiation force excitation. These TTP displacements are inversely proportional to shear stiffness and are dependent on the excitation-beam geometry. Lookup tables (LUTs) specific to an excitation/displacement tracking transducer configuration were generated from simulated data, and shear stiffnesses were estimated from experimental data as a function of depth using the LUTs. Quantitative ROETTP shear elasticity images of spherical inclusions in a calibrated tissue-mimicking phantom have been generated. Shear wave reflections and interference can lead to an underestimation of the absolute reconstructed shear modulus (20–25%), but the ratio of absolute shear stiffnesses is well-preserved (3.3 vs. 3.5).

Copyright © 2009 by ASME

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In