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Tissue-Engineered Cartilage in Three-Dimensional Cultured Chondrocytes by Ultrasound Stimulation and Collagen Sponge as Scaffold

[+] Author Affiliations
Toshihiko Shiraishi, Ietomo Matsunaga, Shin Morishita

Yokohama National University, Yokohama, Kanagawa, Japan

Ryohei Takeuchi, Tomoyuki Saito

Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan

Yuko Mikuni-Takagaki

Kanagawa Dental College, Yokosuka, Kanagawa, Japan

Paper No. IMECE2009-11107, pp. 463-464; 2 pages
  • ASME 2009 International Mechanical Engineering Congress and Exposition
  • Volume 2: Biomedical and Biotechnology Engineering
  • Lake Buena Vista, Florida, USA, November 13–19, 2009
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4375-8 | eISBN: 978-0-7918-3863-1
  • Copyright © 2009 by ASME


This paper describes the effects of ultrasound stimulation on chondrocytes in three-dimensional culture in relation to the production of regenerative cartilage tissue, using collagen sponges as a carrier and supplementation with hyaluronic acid (used in the conservative treatment of osteoarthritis). It has been shown that cell proliferation and matrix production can be facilitated by considering the mechanical environment of the cultured chondrocytes and the mechanical properties of the scaffold structure used in the culture and of the stimulation used.

Copyright © 2009 by ASME



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