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Biomechanics of Glaucoma: A Parametric Study of Flow in Schlemm’s Canal

[+] Author Affiliations
Carolyn Stolfi, Jenn S. Rossmann

Lafayette College, Easton, PA

Paper No. IMECE2009-12355, pp. 207-212; 6 pages
doi:10.1115/IMECE2009-12355
From:
  • ASME 2009 International Mechanical Engineering Congress and Exposition
  • Volume 2: Biomedical and Biotechnology Engineering
  • Lake Buena Vista, Florida, USA, November 13–19, 2009
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4375-8 | eISBN: 978-0-7918-3863-1
  • Copyright © 2009 by ASME

abstract

Glaucoma is one of the most common causes of blindness, affecting approximately seventy million people. Glaucoma is typically caused by high intraocular pressures due to increased outflow resistance, which is primarily concentrated within the trabeculae meshwork and the canal of Schlemm. Debris within trabecular spaces can complicate and limit formation and reabsorption of aqueous humor, leading to elevated interocular pressures. In this study, the biomechanics of Primary Open-Angle Glaucoma are investigated. Computational modeling in physiologically realistic geometries is performed to examine the relationship between intraocular pressure and downstream trabecular and canal resistance. The governing equations for fluid flow are solved, and the influence of such factors as tissue porosity is evaluated. Increased understanding of the biomechanics of glaucoma can improve diagnosis and treatment of this disease.

Copyright © 2009 by ASME

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