Full Content is available to subscribers

Subscribe/Learn More  >

Effects of Process Parameters on Cell Damage in a 3D Cell Printing Process

[+] Author Affiliations
Karen Chang Yan, Kamila Paluch

The College of New Jersey, Ewing, NJ

Kalyani Nair

Bradley University, Peoria, IL

Wei Sun

Drexel University, Philadelphia, PA

Paper No. IMECE2009-11528, pp. 75-81; 7 pages
  • ASME 2009 International Mechanical Engineering Congress and Exposition
  • Volume 2: Biomedical and Biotechnology Engineering
  • Lake Buena Vista, Florida, USA, November 13–19, 2009
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4375-8 | eISBN: 978-0-7918-3863-1
  • Copyright © 2009 by ASME


Various types of bio-fabrication methods have been developed to manufacture products with living cells incorporated via mechanical means. One of fundamental questions that need to be answered is whether cells remain viable and/or functional when subjected to these mechanical disturbances. In this paper, we focus on a 3D cell-printing process via pressure induced deposition. Our experimental studies show that process parameters such as pressure applied and nozzle size affect the cell viability. Given that the cells are suspended in the alginate solution during the printing process, Computational Fluid Dynamic (CFD) analysis is employed to model the pressure-driven flow system and determine the local environment that the living cells are in under varying process parameters. Effects of obtained wall shear stress and exposure time are examined in terms of cell damage based on the corresponding experimental data.

Copyright © 2009 by ASME
Topics: Printing



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In