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Effects of Scaffold Design Parameters and Local Environment on Biopolymer Scaffold Degradation

[+] Author Affiliations
Karen Chang Yan, Christina Roros, Maria Swift

The College of New Jersey, Ewing, NJ

Wei Sun

Drexel University, Philadelphia, PA

Paper No. IMECE2009-11482, pp. 25-26; 2 pages
  • ASME 2009 International Mechanical Engineering Congress and Exposition
  • Volume 2: Biomedical and Biotechnology Engineering
  • Lake Buena Vista, Florida, USA, November 13–19, 2009
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4375-8 | eISBN: 978-0-7918-3863-1
  • Copyright © 2009 by ASME


Biodegradable polymers have been extensively used in tissue engineering as temporary porous scaffolding structures to host or guide tissue/organ regeneration. The advantage lies in that the polymers degrade away harmlessly in the body. One key requirement in tissue scaffold design is to control the scaffolding degradation and erosion that synchronize the new cell/tissue growth. The degradation and/or erosion for biodegradable polymers are influenced by a multitude of factors. This paper presents an in vitro experimental study to examine effects of scaffold design parameters and local environment on the degradation rate of biopolymer scaffolds. Parameters considered are scaffold pore size, material composition and cellular activity.

Copyright © 2009 by ASME
Topics: Design



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