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In Vitro Testing of Living Aortic Heart Valves Using a Pulsatile Bioreactor

[+] Author Affiliations
Leslie N. Sierad, Dan Simionescu

Clemson University, Clemson, SC

Paper No. BioMed2008-38063, pp. 89-90; 2 pages
doi:10.1115/BioMed2008-38063
From:
  • ASME 2008 3rd Frontiers in Biomedical Devices Conference
  • ASME 2008 3rd Frontiers in Biomedical Devices Conference
  • Irvine, California, USA, June 18–20, 2008
  • Conference Sponsors: Nanotechnology Institute
  • ISBN: 0-7918-4833-7 | eISBN: 0-7918-3823-4
  • Copyright © 2008 by ASME

abstract

Valvular heart disease results in approximately 275,000 valve replacement procedures performed annually worldwide. Structural deterioration, calcification, tissue overgrowth, and thromboembolism frequently lead to abnormal tissue stiffness levels that contribute to the failure of native heart valves. While many treatment alternatives exist, understanding the factors that regulate the activity of heart valve cells is critical for circumventing pathological heart valve fibrosis and engineering improved biologically active heart valve replacements.

Copyright © 2008 by ASME
Topics: Testing , Valves , Bioreactors

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