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Tools for Nanosurgery: Applying Carbon Nanopipettes to Cell Physiology

[+] Author Affiliations
Michael G. Schrlau, Haim H. Bau

University of Pennsylvania, Philadelphia, PA

Paper No. BioMed2008-38053, pp. 43-44; 2 pages
doi:10.1115/BioMed2008-38053
From:
  • ASME 2008 3rd Frontiers in Biomedical Devices Conference
  • ASME 2008 3rd Frontiers in Biomedical Devices Conference
  • Irvine, California, USA, June 18–20, 2008
  • Conference Sponsors: Nanotechnology Institute
  • ISBN: 0-7918-4833-7 | eISBN: 0-7918-3823-4
  • Copyright © 2008 by ASME

abstract

There is a need in medical and biological research to probe cells with high spatial resolution. We have developed a method for fabricating integrated carbon nanopipes with diameters ranging from 10’s to 100’s of nanometers to form carbon nanopipettes (CNPs) without the need for cumbersome assembly. CNPs are easily adapted to standard cell physiology equipment and simultaneously provide an accessible nanoscale channel for mass transport and a conductive pathway for electrical measurements. We present the fabrication method, the characterization of the device, and their ability to inject fluids into cells, specifically, calcium mobilizing second messengers.

Copyright © 2008 by ASME

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