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Implantable Minipump With MEMS Electrothemal Valve for Bolus Injection in Mice

[+] Author Affiliations
T. K. Givrad, J.-M. I. Maarek, P. Y. Li, E. Meng, N. Sardesai, D. P. Holschneider

University of Southern California, Los Angeles, CA

Paper No. BioMed2008-38086, pp. 35-36; 2 pages
  • ASME 2008 3rd Frontiers in Biomedical Devices Conference
  • ASME 2008 3rd Frontiers in Biomedical Devices Conference
  • Irvine, California, USA, June 18–20, 2008
  • Conference Sponsors: Nanotechnology Institute
  • ISBN: 0-7918-4833-7 | eISBN: 0-7918-3823-4
  • Copyright © 2008 by ASME


An implantable, single-use miniature infusion pump (MIP) was designed to allow radiotracer injection and functional neuroimaging in freely moving mice. The pump comprises a pressurized reservoir, and a parylene electrothermal valve, which opens to inject tracer through an intravenous catheter into the circulation. A 3-layer 300 μl elastomeric reservoir was built by molding silicone in two-part metal casts. The valve was powered by inductive power transfer from an external 20 cm diameter primary coil to an implanted miniature 8-turn, 1.6 cm diameter Litz-wire secondary coil capable of generating 150 mW at the frequency of 2 MHz.

Copyright © 2008 by ASME



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