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Testing of a Pumpless MEMS Microinjection Needle Employing Electrostatic Attraction and Repulsion of DNA

[+] Author Affiliations
Quentin T. Aten, Brian D. Jensen, Sandra H. Burnett

Brigham Young University, Provo, UT

Paper No. DETC2008-49548, pp. 723-730; 8 pages
doi:10.1115/DETC2008-49548
From:
  • ASME 2008 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference
  • Volume 4: 20th International Conference on Design Theory and Methodology; Second International Conference on Micro- and Nanosystems
  • Brooklyn, New York, USA, August 3–6, 2008
  • Conference Sponsors: Design Engineering Division and Computers in Engineering Division
  • ISBN: 978-0-7918-4328-4 | eISBN: 0-7918-3831-5
  • Copyright © 2008 by ASME

abstract

The ultimate goal of this work is to develop an automated MEMS-based lab-on-a-chip microinjector. This paper outlines one phase of that work: testing the feasibility of a pumpless, polysilicon MEMS microneedle for use in the proposed MEMS-based lab-on-a-chip microinjector. The pumpless MEMS microneedle operates on the principle of attraction and repulsion of DNA using electrostatic charges. Prototype microneedles were fabricated using a multi-layer surface micromachining process. DNA stained with a fluorescent dye (4‘, 6-DIAMIDINO-2-PHENYLINDOLE DIHYDROCHLORIDE or DAPI) was visualized using fluorescent illumination as the DNA was attracted to and repelled from the tips of MEMS microneedles using a 1.5 V DC source. The pumpless MEMS microneedle represents an important and significant step in the development of a self-contained, automated, MEMS-based microinjection system.

Copyright © 2008 by ASME

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