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Bio-Assays Using Bio-Functionalized Magnetic Nanoparticles

[+] Author Affiliations
Chin-Yih Hong

Nan-Kai Institute of Technology, Nantou, Taiwan

Herng-Er Horng

National Taiwan Normal University, Taipei, Taiwan

Hong-Chang Yang

National Taiwan University, Taipei, Taiwan

Shieh-Yueh Yang

MagQu Company Ltd., Sijhih, Taiwan

Paper No. DETC2008-49503, pp. 719-722; 4 pages
doi:10.1115/DETC2008-49503
From:
  • ASME 2008 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference
  • Volume 4: 20th International Conference on Design Theory and Methodology; Second International Conference on Micro- and Nanosystems
  • Brooklyn, New York, USA, August 3–6, 2008
  • Conference Sponsors: Design Engineering Division and Computers in Engineering Division
  • ISBN: 978-0-7918-4328-4 | eISBN: 0-7918-3831-5
  • Copyright © 2008 by ASME

abstract

Biocompatible magnetic nano-particles show great potential in bio-magnetic applications. In this work, the feasibility of magnetically labeled immunoassay using bio-compatible magnetic nanoparticles is investigated. To do this, we study the synthesis technologies for magnetic nano-particles Fe3O4, as well as the coating of various bio-probes onto the magnetic nanoparticles to detect bio-targets, such as proteins, virus, etc. Furthermore, the measurement, magnetoreduction assay, for the amount of bio-targets are developed. The results show such merits as high-sensitivity, high-specificity, high-convenience for magnetoreduction assays using magnetic nanoparticles. The whole assay platform is promisingly applied to food inspection, environment monitoring, and even human diagnosis.

Copyright © 2008 by ASME

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