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The Conceptual Design of a Perfusion Reactor Using a Complexity Measure

[+] Author Affiliations
Andreas Bischof

Technical University Berlin, Berlin, Germany

Jorge Angeles

McGill University, Montreal, QC, Canada

Lucienne Blessing

Université du Luxembourg, Luxembourg

Paper No. DETC2008-49266, pp. 429-436; 8 pages
  • ASME 2008 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference
  • Volume 4: 20th International Conference on Design Theory and Methodology; Second International Conference on Micro- and Nanosystems
  • Brooklyn, New York, USA, August 3–6, 2008
  • Conference Sponsors: Design Engineering Division and Computers in Engineering Division
  • ISBN: 978-0-7918-4328-4 | eISBN: 0-7918-3831-5
  • Copyright © 2008 by ASME


The conceptual design of a perfusion reactor is the subject of this paper. The main objective of the reactor is the provision of nutrients to living cells grown in a porous medium fabricated of a given ceramic foam. In order to increase reactor throughput, the nutrients should be provided in a minimum time, without affecting the cell life. Various layouts of identical ceramic-foam pieces hosting the cells are proposed, the purpose being to select the variant with the highest likelihood of optimum performance, in the absence of a detailed mathematical model. A simple model is proposed, drawn from the discipline of hydraulic dynamical systems, which leads to a flow-complexity measure. The variant with the lowest complexity is then selected, for which a possible embodiment is proposed.

Copyright © 2008 by ASME



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