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Development of Gating Nanopores for Next-Generation DNA Sequencing Using Mechanically Controllable Break Junctions

[+] Author Affiliations
Masateru Taniguchi, Tomoji Kawai

Osaka University, Ibaraki, Osaka, Japan

Paper No. AJK2011-36014, pp. 335-338; 4 pages
doi:10.1115/AJK2011-36014
From:
  • ASME-JSME-KSME 2011 Joint Fluids Engineering Conference
  • ASME-JSME-KSME 2011 Joint Fluids Engineering Conference: Volume 2, Fora
  • Hamamatsu, Japan, July 24–29, 2011
  • Conference Sponsors: Fluids Engineering Division
  • ISBN: 978-0-7918-4441-0
  • Copyright © 2011 by JSME

abstract

We have developed two types of devices—vertical and parallel—for incorporating a microfluidic channel into a gating nanopore. The vertical device consists of a single nanogap electrode with a nanopore perpendicular to the surface of a silicon substrate. The parallel device is similar, except the nanopore is parallel to the surface of the substrate. Furthermore, while the vertical device was fabricated using nanofabrication technologies, the parallel device was fabricated using a mechanically controllable break junction that enables atomic-level control of the electrode gap; hence, measurement of single atoms and molecules is possible. Both devices can identify single gold nanoparticles passing through them by measuring the strength of their electrical signals. The parallel device can also identify the individual nucleotides in a DNA molecule.

Copyright © 2011 by JSME
Topics: Junctions , Nanopores , DNA

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