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Size-Exclusion Surface Plasmon Resonance Sensing With a Microslit Array Chip

[+] Author Affiliations
Noriko Nagase, Kazunori Shimizu, Seiko Shimamoto, Kyohei Terao, Takaaki Suzuki, Fumikazu Oohira

Kagawa University, Takamatsu, Kagawa, Japan

Nobumitsu Miyanishi

Toyo University, Izumino, Gunma, Japan

Paper No. AJK2011-36012, pp. 325-328; 4 pages
doi:10.1115/AJK2011-36012
From:
  • ASME-JSME-KSME 2011 Joint Fluids Engineering Conference
  • ASME-JSME-KSME 2011 Joint Fluids Engineering Conference: Volume 2, Fora
  • Hamamatsu, Japan, July 24–29, 2011
  • Conference Sponsors: Fluids Engineering Division
  • ISBN: 978-0-7918-4441-0
  • Copyright © 2011 by JSME

abstract

In this study, we propose a novel surface plasmon resonance (SPR) chip on which the microslit array was fabricated. The microslit excludes micrometer-size objects that are larger than its slit size from sensing field, so that it acts as a filter. In order to confirm the filtereffect, we demonstrated the sensing of microparticles of different diameters using the SPR chip. As the demonstration of the biotechnology application, we performed the discrimination of aggregation of bio-molecules using SGNP (Sugar chain imobilized Gold Nano Particle) as a model sample.

Copyright © 2011 by JSME

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