Full Content is available to subscribers

Subscribe/Learn More  >

Oxygen-Sensing Microfluidic Scaffolds

[+] Author Affiliations
Nak Won Choi, Scott S. Verbridge, Rebecca M. Williams, Warren R. Zipfel, Claudia Fischbach, Abraham D. Stroock

Cornell University, Ithaca, NY

Kang-Yeol Park

Samsung Cheil Industries Incorporation, Uiwang, Republic of Korea

Paper No. ICNMM2009-82292, pp. 1185-1189; 5 pages
  • ASME 2009 7th International Conference on Nanochannels, Microchannels, and Minichannels
  • ASME 2009 7th International Conference on Nanochannels, Microchannels and Minichannels
  • Pohang, South Korea, June 22–24, 2009
  • Conference Sponsors: Nanotechnology Institute
  • ISBN: 978-0-7918-4349-9 | eISBN: 978-0-7918-3850-1
  • Copyright © 2009 by ASME


Oxygen in living tissues is a key soluble factor in normal as well as pathological processes. In relation to cancer, the development of oxygen-depleted tumor niches is thought to play an important role in tumor growth and metastasis. An outstanding challenge remains to develop an in vitro system where one can control and monitor oxygen concentration in a spatiotemporal manner within a three-dimensional (3-D) cell-seeded tissue scaffold. We propose the development of oxygen-sensing microfluidic scaffolds, which meet this challenge. Our strategies include 1) the synthesis of oxygen-sensing microbeads, 2) characterization of the beads via both direct imaging of phosphorescence and measurement of phosphorescence lifetime, and 3) visualization and measurement of oxygen-depletion lengths in a simple microfluidic tumor model.

Copyright © 2009 by ASME
Topics: Microfluidics , Oxygen



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In