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Measurement of Intracellular Drug Concentration in a Single Cancer Cell Isolated in a Microfabricated Biochip for Cancer Diagnosis

[+] Author Affiliations
Paul Li, Derek Chew

Simon Fraser University, Burnaby, BC, Canada

Paper No. MicroNano2008-70164, pp. 499-501; 3 pages
doi:10.1115/MicroNano2008-70164
From:
  • 2008 Second International Conference on Integration and Commercialization of Micro and Nanosystems
  • 2008 Second International Conference on Integration and Commercialization of Micro and Nanosystems
  • Clear Water Bay, Kowloon, Hong Kong, June 3–5, 2008
  • Conference Sponsors: Nanotechnology Institute
  • ISBN: 0-7918-4294-0 | eISBN: 0-7918-3819-6
  • Copyright © 2008 by ASME

abstract

A microfluidic biochip has been fabricated to retain a single cell (e.g. a cancerous cell) within a U-shaped cell retention structure for real-time monitoring of cellular changes over long periods of time (hours). Experiments illustrate the cell heterogeneity in drug responses, and demonstrate the significance of the microchip platform for cancer diagnosis. This microdevice provides a clinical diagnostic platform to evaluate multi-drug-resistance in cancer patients. This device may increase the effectiveness of current chemotherapeutic strategies by evaluating an individual’s cellular response to these agents.

Copyright © 2008 by ASME

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