Full Content is available to subscribers

Subscribe/Learn More  >

Measurement of Intracellular Drug Concentration in a Single Cancer Cell Isolated in a Microfabricated Biochip for Cancer Diagnosis

[+] Author Affiliations
Paul Li, Derek Chew

Simon Fraser University, Burnaby, BC, Canada

Paper No. MicroNano2008-70164, pp. 499-501; 3 pages
  • 2008 Second International Conference on Integration and Commercialization of Micro and Nanosystems
  • 2008 Second International Conference on Integration and Commercialization of Micro and Nanosystems
  • Clear Water Bay, Kowloon, Hong Kong, June 3–5, 2008
  • Conference Sponsors: Nanotechnology Institute
  • ISBN: 0-7918-4294-0 | eISBN: 0-7918-3819-6
  • Copyright © 2008 by ASME


A microfluidic biochip has been fabricated to retain a single cell (e.g. a cancerous cell) within a U-shaped cell retention structure for real-time monitoring of cellular changes over long periods of time (hours). Experiments illustrate the cell heterogeneity in drug responses, and demonstrate the significance of the microchip platform for cancer diagnosis. This microdevice provides a clinical diagnostic platform to evaluate multi-drug-resistance in cancer patients. This device may increase the effectiveness of current chemotherapeutic strategies by evaluating an individual’s cellular response to these agents.

Copyright © 2008 by ASME



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In