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DNA-Lipophilic Vitamins Supramolecular Complexes

[+] Author Affiliations
Ashraf S. Elkady

Atomic Energy Authority, Abou-Zabal, Egypt

Paper No. MN2008-47031, pp. 213-216; 4 pages
doi:10.1115/MN2008-47031
From:
  • ASME 2008 2nd Multifunctional Nanocomposites and Nanomaterials International Conference
  • ASME 2008 2nd Multifunctional Nanocomposites and Nanomaterials
  • Sharm El Sheikh, Egypt, January 11–13, 2008
  • Conference Sponsors: Nanotechnology Institute
  • ISBN: 0-7918-4291-6 | eISBN: 1-7918-3814-5
  • Copyright © 2008 by ASME

abstract

The self-assembly of supramolecular complexes between DNA and lipophilic vitamins, e.g. vitamin D group was examined, in the absence and presence of different cations, to the first time. A novel method for preparing DNA-lipophilic vitamins nanostructured complexes in the existence of divalent cations is introduced. The nanostructure of the supramolecular complexes ranged from beads-on-strings to compact globules and liquid crystalline forms depending on the vitamin nature, cations concentration and incubation time. A nucleation mechanism and flower-like aggregates are proposed as an initial state for complex formation. The biomedical applications of the functional nanostructured supramolecular complexes will be discussed in details.

Copyright © 2008 by ASME
Topics: DNA

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