0

Full Content is available to subscribers

Subscribe/Learn More  >

Wetting Characteristics of a Phospholipid Membrane Using Molecular Dynamics Simulation

[+] Author Affiliations
Shalabh C. Maroo, H. Jeremy Cho, Evelyn N. Wang

Massachusetts Institute of Technology (MIT), Cambridge, MA

Paper No. IMECE2010-40671, pp. 919-924; 6 pages
doi:10.1115/IMECE2010-40671
From:
  • ASME 2010 International Mechanical Engineering Congress and Exposition
  • Volume 10: Micro and Nano Systems
  • Vancouver, British Columbia, Canada, November 12–18, 2010
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4447-2
  • Copyright © 2010 by ASME

abstract

Phospholipid molecules form bilayers in water due to their hydrophilic heads and hydrophobic tails. The electroporation of lipid bilayers (cell membranes) is a phenomenon where membranes are permeabilized by the application of electric fields. At some critical voltage, a dramatic increase in conductivity across the membranes is observed. This phenomenon is widely used in DNA and RNA transfer as well as targeted drug delivery systems. However, the membrane ruptures with a continuous increase in voltage where interaction between lipid and water molecules is an important factor in electroporation behavior. This study characterizes the wettability, of both the head and tail groups of lipid molecules, by calculating the contact angle of a water droplet on a planar phospholipid monolayer using molecular dynamics simulations. The water droplet completely spreads on the hydrophilic heads of the lipid, while forming an average contact angle of 136.05° on the hydrophobic tails. An analysis using the Young’s equation suggests that a difference in free energy of 116 mJ/m2 contributes to the overall energy barrier for water penetration across the lipid monolayer. We aim to control this permeabilization phenomenon to achieve water desalination.

Copyright © 2010 by ASME

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In