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Cytotoxicity of Magnetic Nanocomposite Spheres for Possible Drug Delivery Systems

[+] Author Affiliations
R. Asmatulu, A. Garikapati, H. E. Misak, Z. Song, S.-Y. Yang, P. Wooley

Wichita State University, Wichita, KS

Paper No. IMECE2010-40269, pp. 911-918; 8 pages
doi:10.1115/IMECE2010-40269
From:
  • ASME 2010 International Mechanical Engineering Congress and Exposition
  • Volume 10: Micro and Nano Systems
  • Vancouver, British Columbia, Canada, November 12–18, 2010
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4447-2
  • Copyright © 2010 by ASME

abstract

Cytotoxicity test is a rapid and standardized in vitro method to determine the harmful effects of materials used for biomedical purposes, such as drug carriers, implants and their coatings, biosensors and surgical/medical devices. In the present study, sol-gel driven nickel ferrite (NiFe2 O4 ) and cobalt ferrite (CoFe2 O4 ) nanoparticles (10–25 nm) at different concentrations were incorporated into biodegradable polymer, poly(lactic-co-glycolic acid) (PLGA), using oil-in-oil emulsion/solvent evaporation technique, and then the cytotoxicity of magnetic nanocomposite spheres was characterized using raw cells. The test provides the toxicity of the products prior to their real applications, which may limit animal experimentation, remove potential toxic compounds and reduce the downstream costs. The cytotoxicity results showed that both magnetic nanocomposite spheres were toxic at some degree to the raw cells; however, the cobalt ferrite nanoparticles in nanocomposite spheres are more toxic than the nickel ferrite nanoparticles.

Copyright © 2010 by ASME

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