Full Content is available to subscribers

Subscribe/Learn More  >

Three Dimensional Simulation of Dynamics and Deformation of Red Blood Cells in Capillary Flow

[+] Author Affiliations
Toru Yamada, Anurag Kumar, Mohammad Faghri

University of Rhode Island, Kingston, RI

Yutaka Asako

Tokyo Metropolitan University, Hachioji, Tokyo, Japan

Paper No. IMECE2010-39140, pp. 905-910; 6 pages
  • ASME 2010 International Mechanical Engineering Congress and Exposition
  • Volume 10: Micro and Nano Systems
  • Vancouver, British Columbia, Canada, November 12–18, 2010
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4447-2
  • Copyright © 2010 by ASME


A three-dimensional computational model using dissipative particle dynamics (DPD) is developed to simulate dynamics and deformation of red cells (RBC) in capillaries. DPD is able to produce correct hydrodynamics of the flow and incorporate microscopic detail of various segments of the cell. RBC is constructed using DPD particles, which are connected by a spring network to represent the membrane. The total energy of the RBC is associated with the bending energy, in-plane shear energy and the constraints of fixed area and volume. Shape optimization of swollen RBC due to continuous deflation based on the minimum energy principle is conducted to obtain the biconcave shape in equilibrium. Then, an external force is applied to the cell to study the large deformation in axial and lateral direction and compared with the experimental results. Also, RBC is placed inside a 10 μm capillary flow to study the dynamics and deformation of the cell. The cell undergoes steady deformation and acquires parachute type shape as observed in experiments.

Copyright © 2010 by ASME



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In