Full Content is available to subscribers

Subscribe/Learn More  >

Direct-Deposition and Multiple Materials Integration of Tissue Engineering Scaffolds

[+] Author Affiliations
Chuang Wei, Bhushan Sonawane, Jingyan Dong

North Carolina State University, Raleigh, NC

Lei Cai, Shanfeng Wang

The University of Tennessee, Knoxville, Knoxville, TX

Paper No. IMECE2010-37922, pp. 1083-1088; 6 pages
  • ASME 2010 International Mechanical Engineering Congress and Exposition
  • Volume 3: Design and Manufacturing, Parts A and B
  • Vancouver, British Columbia, Canada, November 12–18, 2010
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4427-4
  • Copyright © 2010 by ASME


High-aspect-ratio three-dimensional structures using biocompatible materials are critical for tissue engineering applications. This study develops a multi-nozzle direct-write approach to construct tissue engineering scaffolds with complex three-dimensional structures utilizing polymeric materials. This approach provides the capability to fabricate three dimensional scaffolds by depositing biocompatible UV-curable polymeric material and thermoplastic material (paraffin wax) layer-by-layer, which respectively are used as structural material and supporting material that will be removed later on. The designed structure is built by selectively extruding drops and/or filament through a set of syringes that host different functional materials, following a layer-by-layer sequence. The location of the deposition is precisely controlled by a high precision three-dimensional translational stage. After different structural/functional materials and the supporting material are deposited with predesigned pattern, the supporting material is removed by using appropriate chemical solvent which will not affect physical and chemical properties of the designed structure. The mechanical property of the structure, the equilibrium modulus and dynamic stiffness, can be engineered by designing different pore size for the scaffold. The multi-nozzle based direct writing approach provides a practical solution to build scaffolds for tissue engineering and integrate multiple functional materials together into a single scaffold structure.

Copyright © 2010 by ASME



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In