Full Content is available to subscribers

Subscribe/Learn More  >

Enhancement of RF Ablation by Combined Use of Ultra-Low Temperature Fluid Cooling and Magnetic Nanoparticles

[+] Author Affiliations
Zhong-Shan Deng

Chinese Academy of Sciences, Beijing, China

Jing Liu

Chinese Academy of Sciences; Tsinghua University, Beijing, China

Paper No. IMECE2010-38021, pp. 209-213; 5 pages
  • ASME 2010 International Mechanical Engineering Congress and Exposition
  • Volume 2: Biomedical and Biotechnology Engineering
  • Vancouver, British Columbia, Canada, November 12–18, 2010
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4426-7
  • Copyright © 2010 by ASME


Magnetic nanoparticles with high electrical conductivity have been proved to be effective in enhancing the efficacy of RF ablation. However, the possible carbonization of tissues is an unfavorable factor in achieving greater dimensions of necrosis, because carbonized tissue is a poor conductor, increases impedance and limits propagation area of RF energy. To prevent potential carbonization of tissues surrounding to the heating part of RF electrodes during RF ablation, a new method using ultra-low temperature fluid was proposed for cooling RF electrodes and tissues in the vicinity of RF electrodes in this study. To test its feasibility, the corresponding bioheat transfer process during RF ablation simultaneously applying this cooling method and magnetic nanoparticles was studied through numerical simulations. The results indicate that the cooling method by ultra-low temperature fluid can prevent carbonization of tissues resulted by local high temperature, significantly enlarge the effective heating area and thus actualize highly efficient thermal coagulation to tumor tissues during RF ablation with adjuvant use of magnetic nanoparticles.

Copyright © 2010 by ASME



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In