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Model Predictive Control of an Electroporation Process

[+] Author Affiliations
Peinan Ge, Jingang Yi, Jianbo Li, Hao Lin

Rutgers University, Piscataway, NJ

Paper No. DSCC2010-4243, pp. 437-443; 7 pages
doi:10.1115/DSCC2010-4243
From:
  • ASME 2010 Dynamic Systems and Control Conference
  • ASME 2010 Dynamic Systems and Control Conference, Volume 1
  • Cambridge, Massachusetts, USA, September 12–15, 2010
  • Conference Sponsors: Dynamic Systems and Control Division
  • ISBN: 978-0-7918-4417-5 | eISBN: 978-0-7918-3884-6
  • Copyright © 2010 by ASME

abstract

Electroporation is an elegant means to deliver molecules into the cellular cytoplasm, while simultaneously maintaining cell viability and functionality. Despite extensive research, however, electroporation methods still fall short of the desired efficiency and reliability. We present a model predictive control (MPC) design for enabling highly efficient and reliable electroporation processes. Instead of using one single electrical pulse in current practice, we consider a controlled multi-pulse electroporation based on an MPC framework. The most attractive properties of using MPC design of multi-pulse electroporation are the fast computation of optimal control solutions and the real-time tunability of the electrical field density during the process. We demonstrate the controlled electroporation process through simulation examples.

Copyright © 2010 by ASME

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