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Feedback Control and Exogenous Force Estimation for Improved Single-Molecule Experiments

[+] Author Affiliations
Daniel G. Cole

University of Pittsburgh, Pittsburgh, PA

Paper No. DETC2010-28735, pp. 767-775; 9 pages
  • ASME 2010 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference
  • Volume 4: 12th International Conference on Advanced Vehicle and Tire Technologies; 4th International Conference on Micro- and Nanosystems
  • Montreal, Quebec, Canada, August 15–18, 2010
  • Conference Sponsors: Design Engineering Division and Computers in Engineering Division
  • ISBN: 978-0-7918-4412-0 | eISBN: 978-0-7918-3881-5
  • Copyright © 2010 by ASME


This article explores two types of feedback used to control optical traps: position feedback, which was shown to be equivalent to force feedback, and integral feedback. The ability of each of these types of feedback to lower the measurement SNR in single molecule experiments is evaluated and compared to the open-loop case. While position feedback did not result in any improvement in the SNR, the case of integral feedback results in an improvement. Integral feedback is shown to improve the SNR of the measured signal of interest, and is relatively robust and easy to implement. It is also shown that integral feedback acts as an exogenous force estimator.

Copyright © 2010 by ASME
Topics: Force , Feedback



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