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Computational Investigation of Dynamic Properties of Actin Networks With Crosslinking Proteins

[+] Author Affiliations
Taeyoon Kim, Roger D. Kamm

Massachusetts Institute of Technology, Cambridge, MA

Wonmuk Hwang

Texas A&M University, College Station, TX

Paper No. NEMB2010-13156, pp. 343-344; 2 pages
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • Houston, Texas, USA, February 7–10, 2010
  • Conference Sponsors: ASME Nanotechnology Council
  • ISBN: 978-0-7918-4392-5 | eISBN: 978-0-7918-3866-2
  • Copyright © 2010 by ASME


Due to the increasing recognition of the role that force plays in biological processes, a new field, mechanobiology, has recently emerged. One aspect of this is the need to gain a physical understanding of the viscoelastic properties of the cytoskeleton. Numerous studies, both in living cells and in reconstituted actin gels, have been conducted, but important questions still remain. Of these an important issue revolves around the role played by actin crosslinking proteins (ACPs), and whether they undergo unfolding or unbinding under stress. This issue is complicated by the fact that single molecule studies show that both events occur within a similar range of forces, on the order of 20–100 pN.

Copyright © 2010 by ASME
Topics: Networks , Proteins



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