A Hybrid Model for Nanoparticle Targeted Delivery in Blood Flow PUBLIC ACCESS

[+] Author Affiliations
Yaling Liu, Jifu Tan, Samar Shah

University of Texas at Arlington, Arlington, TX

Paper No. NEMB2010-13253, pp. 307; 1 page
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • Houston, Texas, USA, February 7–10, 2010
  • Conference Sponsors: ASME Nanotechnology Council
  • ISBN: 978-0-7918-4392-5 | eISBN: 978-0-7918-3866-2
  • Copyright © 2010 by ASME


Nanoparticle targeted delivery in vascular system involves the interplay of transport, hydrodynamic force, and multivalent interactions with targeted biosurfaces. Current theoretical studies in nanoparticle therapeutic delivery are limited to nanoparticle suspensions in a Newtonian fluid without blood cells [1–3]. However, blood is a complex biological fluid made of components such as red blood cells (RBC), monocytes, platelets, proteins, etc. The existence of blood cells in the core region of blood streams might change the nanoparticle dispersion and binding through cell-nanoparticle interaction. It is thus important to understand how blood cells influence nanoparticles motion and binding.

Copyright © 2010 by ASME
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