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Pumping Characteristics of the Lymphatic System

[+] Author Affiliations
James E. Moore, Jr.

Texas A&M University, College Station, TX

Paper No. NEMB2010-13034, pp. 257-258; 2 pages
doi:10.1115/NEMB2010-13034
From:
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • Houston, Texas, USA, February 7–10, 2010
  • Conference Sponsors: ASME Nanotechnology Council
  • ISBN: 978-0-7918-4392-5 | eISBN: 978-0-7918-3866-2
  • Copyright © 2010 by ASME

abstract

The lymphatic system is crucial for maintaining fluid and protein balance, and for immune function. It also plays an important role in the spread of cancer. Lymphedema can form when parts of the system are not functioning, such as in patients who have undergone lymph node resection as part of cancer therapy. Lymphedema is a painful, debilitating condition for which there is no cure. This research is aimed at constructing multi-scale models of lymphatic pumping function, incorporating information from the cellular to the whole organ level. Lymphatic endothelial and smooth muscle cell mechanotransduction events are incorporated into a single lymphangion pumping unit. The performance of this pumping unit is shown to exhibit behaviors observed in experiments with rat mesentery.

Copyright © 2010 by ASME

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