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E-cadherin N-glycosylation Modulates the Strength of Adherens Junctions

[+] Author Affiliations
Sarah J. Shareef

Harvard University, Cambridge, MA

Mihai Nita-Lazar, Maria A. Kukuruzinska

Boston University Medical Center, Boston, MA

Paper No. NEMB2010-13013, pp. 255-256; 2 pages
doi:10.1115/NEMB2010-13013
From:
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • Houston, Texas, USA, February 7–10, 2010
  • Conference Sponsors: ASME Nanotechnology Council
  • ISBN: 978-0-7918-4392-5 | eISBN: 978-0-7918-3866-2
  • Copyright © 2010 by ASME

abstract

Metastasis, the spread of cancer cells throughout the body, claims 90% of solid tumor deaths. During metastasis, cancer cells undergo discohesion. An understanding of how to control and strengthen cell adhesion through junction formation could lead to methods for decreasing metastatic tendencies.

Copyright © 2010 by ASME
Topics: Junctions

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