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Preparation of Interconnected Microporous Poly(glycolic-co-lactic acid) With High Hydroxyapatite Loading

[+] Author Affiliations
Wei Zhang, Donggang Yao

Georgia Institute of Technology, Atlanta, GA

Qingwei Zhang, Jack G. Zhou, Peter I. Lelkes

Drexel University, Philadelphia, PA

Paper No. NEMB2010-13119, pp. 199-202; 4 pages
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • Houston, Texas, USA, February 7–10, 2010
  • Conference Sponsors: ASME Nanotechnology Council
  • ISBN: 978-0-7918-4392-5 | eISBN: 978-0-7918-3866-2
  • Copyright © 2010 by ASME


Hydroxyapatite (HA) is known to promote osteogenicity and enhance mechanical strength of biopolymers. However, incorporating a large amount of HA into aporous biopolymer still remains a challenge. In this study, a new method was investigated to incorporate high HA loading into interconnected microporous poly(glycolic-co-lactic acid) (PLGA). Specifically, a tertiary blend comprising PLGA/PS/HA (40/40/20 wt%), prepared by melt blending under conditions for formation of a co-continuous structure, was annealed under small-strain oscillation between parallel plates. The results from different characterizations suggested that the applied small-strain oscillation substantially accelerated the migration of HA nanoparticles during annealing from the PS phase to the PLGA phase; nearly all HA particles were uniformly presented in the PLGA phase after a short period of annealing. After dissolution of the PS phase, a PLGA material with interconnected microporous structure was successfully produced, with a high HA loading above 30 wt%.

Copyright © 2010 by ASME



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