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The Effect of Nano Hydroxyapatite Particles on Morphology and Mechanical Properties of Microcellular Injection Molded Polylactide/Hydroxyapatite Tissue Scaffold

[+] Author Affiliations
Adam Kramschuster

University of Wisconsin-Stout, Menomonie, WI

Lih-Sheng Turng, Wan-Ju Li, Yiyan Peng

University of Wisconsin-Madison, Madison, WI

Jun Peng

South China University of Technology, Guangzhou, China

Paper No. NEMB2010-13290, pp. 175-178; 4 pages
doi:10.1115/NEMB2010-13290
From:
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • Houston, Texas, USA, February 7–10, 2010
  • Conference Sponsors: ASME Nanotechnology Council
  • ISBN: 978-0-7918-4392-5 | eISBN: 978-0-7918-3866-2
  • Copyright © 2010 by ASME

abstract

The current large demands for transplant organs and tissues has led to extensive research on material synthesis and fabrication methods for biodegradable polymeric scaffolds, which are required to have high porosity, well interconnected pore structure, and good mechanical properties. However, the majority of current scaffold fabrication techniques are either for batch processes or use organic solvents, which can be detrimental to cell survival and tissue growth. The ability to mass produce solvent-free, highly porous, highly interconnected scaffolds with complex geometries is essential to provide off-the-shelf availability [1]. Injection molding has long been used for mass production of complex 3D plastic parts. The low-cost manufacturing, repeatability, and design flexibility inherent in the injection molding process make it an ideal manufacturing process to create 3D scaffolds, as long as high porosity and interconnectivity can be imparted into the finished product.

Copyright © 2010 by ASME

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