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Nanomechanics of Electrospun Fibers for Tissue Engineering

[+] Author Affiliations
Stephen Baker, Justin Sigley, Christine Carlisle, Joel Stitzel, Joel Berry, Keith Bonin, Martin Guthold

Wake Forest University, Winston-Salem, NC

Paper No. NEMB2010-13287, pp. 173-174; 2 pages
doi:10.1115/NEMB2010-13287
From:
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • Houston, Texas, USA, February 7–10, 2010
  • Conference Sponsors: ASME Nanotechnology Council
  • ISBN: 978-0-7918-4392-5 | eISBN: 978-0-7918-3866-2
  • Copyright © 2010 by ASME

abstract

Understanding the material properties of the nanofibers comprising electrospun scaffolds for tissue engineering will elucidate the mechanotransduction of cells seeded onto and attached those scaffolds. The overall mechanical properties of any structure built from fibers depend on 1) the architecture, 2) the properties of the constituent single fibers, and 3) the junctions between fibers. All three must be known to design a structure with predictable mechanical properties. We hypothesize that a basic understanding of the nanolevel mechanical properties of individual electrospun fibers will enable accurate prediction of the overall cellular response and bulk mechanical behavior of electrospun tissue scaffolds.

Copyright © 2010 by ASME

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