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Mechanical Regulation of Stem Cell Differentiation on Geometrically Modulated Elastomeric Substrates

[+] Author Affiliations
Jianping Fu

University of Michigan, Ann Arbor, MI

Paper No. NEMB2010-13199, pp. 165-166; 2 pages
doi:10.1115/NEMB2010-13199
From:
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • Houston, Texas, USA, February 7–10, 2010
  • Conference Sponsors: ASME Nanotechnology Council
  • ISBN: 978-0-7918-4392-5 | eISBN: 978-0-7918-3866-2
  • Copyright © 2010 by ASME

abstract

We report the use of micromolded elastomeric micropost arrays to modulate substrate rigidity independently of effects on adhesive and other material surface properties. We demonstrate that micropost rigidity impacts cell morphology, focal adhesions, cytoskeletal contractility, and stem cell differentiation. Furthermore, these micropost arrays reveal that changes in cytoskeletal contractility can precede stem cell differentiation and be utilized as a non-destructive predictor for fate decisions at the single cell level.

Copyright © 2010 by ASME
Topics: Stem cells

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