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Integrated Diagnostics for Rapid Quantitation of Biomarkers in Human Fluids

[+] Author Affiliations
Chenlu Hou, Kelly Karns, Amy E. Herr

University of California, Berkeley, Berkeley, CA

Paper No. NEMB2010-13235, pp. 129-130; 2 pages
doi:10.1115/NEMB2010-13235
From:
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • Houston, Texas, USA, February 7–10, 2010
  • Conference Sponsors: ASME Nanotechnology Council
  • ISBN: 978-0-7918-4392-5 | eISBN: 978-0-7918-3866-2
  • Copyright © 2010 by ASME

abstract

A fast, accurate differential diagnosis is a tremendous challenge in clinical medicine. For example, in emergency settings differential diagnosis of infection from inflammation is needed, as a timely and actionable diagnosis is critical. Consequently, diagnostics capable of measuring multiple biomarkers would support clinical decision-making related to diagnosis, containment, and treatment. Microfluidic assays are exceptionally well-suited for near-patient clinical diagnostics (i.e., ambulance, emergency room, field hospital). We present spectrally multiplexed homogeneous electrophoretic immunoassays for specific protein disease biomarkers. Biomarkers are resolved quickly (< 60 s), in ultra-short separation lengths (< 1 mm), and at clinically relevant concentrations (nM). On-going work will be presented and centers on endogenous protein measurements in clinical samples in support of near-patient assessment.

Copyright © 2010 by ASME

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