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Molecular Delivery Into Live Cells Using Gold Nanoparticle Arrays Fabricated by Polymer Mold Guided Near-Field Photothermal Annealing

[+] Author Affiliations
Ting-Hsiang Wu, Fan Xiao, Sheraz Kalim, Tara Teslaa, Michael A. Teitell, Pei-Yu Chiou

University of California, Los Angeles, Los Angeles, CA

Paper No. NEMB2010-13183, pp. 121-122; 2 pages
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • Houston, Texas, USA, February 7–10, 2010
  • Conference Sponsors: ASME Nanotechnology Council
  • ISBN: 978-0-7918-4392-5 | eISBN: 978-0-7918-3866-2
  • Copyright © 2010 by ASME


A massively-parallel molecular delivery system for mammalian cells is demonstrated by pulsed-laser irradiation of a gold nanoparticle array situated below a cell monolayer. This system is capable of high throughput and spatially-targeted delivery into desired areas of a cell culture by designing the laser irradiation pattern. Rapid fabrication of gold nanoparticle arrays over large areas (>1 mm2 ) is achieved by polymer mold guided near-field photothermal annealing.

Copyright © 2010 by ASME



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