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A Microfluidic Chip for Studying Intercellular Communication via Gap Junction Channels

[+] Author Affiliations
Cédric Bathany, Thomas Suchyna, Susan Z. Hua

SUNY-Buffalo, Buffalo, NY

Paper No. NEMB2010-13135, pp. 119-120; 2 pages
doi:10.1115/NEMB2010-13135
From:
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • Houston, Texas, USA, February 7–10, 2010
  • Conference Sponsors: ASME Nanotechnology Council
  • ISBN: 978-0-7918-4392-5 | eISBN: 978-0-7918-3866-2
  • Copyright © 2010 by ASME

abstract

Cells in tissues and organs coordinate their activities with each other, and this communication is mainly mediated by specialized channels, called Gap Junctions. To date, our understanding of specificity of reagents and extracellular stimuli to gap junctions is very limited. Existing techniques for gap junctions assay are tedious and not convenient. We have developed a microfluidic chip that is capable of detecting chemical diffusion across gap junctions, as well as screening reagents for specific gap junction channels.

Copyright © 2010 by ASME

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