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Micropattern Effect on Breast Cancer Cells Behavior on Isotropically Etched Silicon Microenvironments

[+] Author Affiliations
Mehdi Nikkhah, Jeannine S. Strobl, Bhanu Peddi, Masoud Agah

Virginia Tech, Blacksburg, VA

Adedamola Omotosho

Cornell University, Ithaca, NY

Paper No. NEMB2010-13030, pp. 115-116; 2 pages
doi:10.1115/NEMB2010-13030
From:
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • Houston, Texas, USA, February 7–10, 2010
  • Conference Sponsors: ASME Nanotechnology Council
  • ISBN: 978-0-7918-4392-5 | eISBN: 978-0-7918-3866-2
  • Copyright © 2010 by ASME

abstract

In this paper we are investigating three dimensional (3-D) silicon-based microenvironments as potential platforms for breast cancer diagnostics. We have developed isotropically etched microstructures with a wide range of geometrical patterns for this purpose. Our results indicate that with the etched surface ratio of ∼65%, it is possible to capture 80–90% of the cancer cells within each silicon chip. After treatment of the cells with mitomycin C (to block the cell growth) more number of the cells are trapped inside the etched features for longer cultures times (72 h) suggesting that there is a directed motility and attraction of the cells toward the etched cavities and by optimally designing the etched features, the proposed platforms can be potentially used for diagnostics purposes.

Copyright © 2010 by ASME
Topics: Cancer , Silicon

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