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Enhanced Generation of Reactive Oxygen Species Using Gold Nanoparticles Conjugated With Protoporphyrin IX

[+] Author Affiliations
Maung Kyaw Khaing Oo, Hongjun Wang, Henry Du

Stevens Institute of Technology, Hoboken, NJ

Maria Gomez

Drew University, Madison, NJ

Paper No. NEMB2010-13115, pp. 93-94; 2 pages
doi:10.1115/NEMB2010-13115
From:
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • Houston, Texas, USA, February 7–10, 2010
  • Conference Sponsors: ASME Nanotechnology Council
  • ISBN: 978-0-7918-4392-5 | eISBN: 978-0-7918-3866-2
  • Copyright © 2010 by ASME

abstract

Reactive oxygen species (ROS) is a vital trigger for photodynamic therapy (PDT) of cancer. We report the production of elevated ROS using gold nanoparticles (GNP) (20–100 nm in diameter) conjugated with Protophorphyrin IX (PpIX). The amount of ROS formation increases with the size of the GNP due to enhanced electromagnetic field resulting from localized surface plasmonic resonance.

Copyright © 2010 by ASME
Topics: Nanoparticles , Oxygen

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