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Magnetic Targeting of Therapeutics

[+] Author Affiliations
Kenneth Dormer, Sunny Po, Benjamin Scherlag, Isaac Rutel, David Bourne, Kar-Ming Fung

University of Oklahoma HSC, Oklahoma City, OK

Kejian Chen, Satish Kyriyavar, Xinsheng Gao, Xiaoping Du, Richard Kopke

Hough Ear Institute, Oklahoma City, OK

Kytai Nguyen

University of Texas - Arlington, Arlington, TX

Brian Grady

University of Oklahoma, Norman, OK

Benjamin Shapiro

University of Maryland, College Park, MD

Paper No. NEMB2010-13022, pp. 85-86; 2 pages
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • Houston, Texas, USA, February 7–10, 2010
  • Conference Sponsors: ASME Nanotechnology Council
  • ISBN: 978-0-7918-4392-5 | eISBN: 978-0-7918-3866-2
  • Copyright © 2010 by ASME


Multiple formulations of nano-sized particles, capsules, dendrimers, lipids, ceramics and genetic materials are being investigated in multiple labs for delivery of therapeutic moieties to targeted tissues. Interest is driven by reducing health care costs while increasing therapeutic efficacy and cost of treatment. One technology, magnetic targeting, incorporates iron oxide nanoparticles, to target nanomedicine payloads, down the gradients of external magnetic fields. When iron oxide crystal domains are less than ∼20–40 nm, particles become superparamagnetic (SPION), that is exhibit no remanent induction but very high magnetic susceptibility in the presence of an external magnetic field. Thus, targeting can be vectored by magnetic lines of flux. Particles can be pulled out of the microcirculation and across membranes into tissues. Two target organs that can employ magnetic targeting are the heart (epicardium) and inner ear (cochlea).

Copyright © 2010 by ASME



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