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A New Platform for Profiling Active Proteases With Single-Molecule Sensitivity

[+] Author Affiliations
M. Yüsra Satoğlu Doğan, Andrey Revyakin, Sang Park, Alexandros Pertsinidis

University of California at Berkeley, Berkeley, CA

Christopher Brown, Charles S. Craik

University of California, San Francisco, CA

Steven Chu, Arun Majumdar

Department of Energy, Washington, DC

Paper No. NEMB2010-13383, pp. 77-78; 2 pages
doi:10.1115/NEMB2010-13383
From:
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • Houston, Texas, USA, February 7–10, 2010
  • Conference Sponsors: ASME Nanotechnology Council
  • ISBN: 978-0-7918-4392-5 | eISBN: 978-0-7918-3866-2
  • Copyright © 2010 by ASME

abstract

Proteases, such as urokinase plasminogen activator (uPA) and prostate specific antigen (PSA), have been used extensively as biomarkers for cancer. A necessary improvement in diagnostics with proteomics is to use the activity levels of proteases as a signal, as opposed to the total protease content. This will provide a better functional insight into the propagation of cancer, and ultimately could allow us to diagnose cancer at earlier stages. Here, we propose a new platform to capture and measure activity of specific proteases in patient samples, with single-molecule sensitivity.

Copyright © 2010 by ASME
Topics: Cancer , Signals

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