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Platelet Nano-Forces are Similar on Fibronectin and Fibrinogen Ligands

[+] Author Affiliations
Xin M. Liang, Nathan J. Sniadecki

University of Washington, Seattle, WA

Paper No. NEMB2010-13278, pp. 55-56; 2 pages
doi:10.1115/NEMB2010-13278
From:
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • Houston, Texas, USA, February 7–10, 2010
  • Conference Sponsors: ASME Nanotechnology Council
  • ISBN: 978-0-7918-4392-5 | eISBN: 978-0-7918-3866-2
  • Copyright © 2010 by ASME

abstract

We present a new biomechanical approach to measure nanoscale platelet contractile forces, which play an important role in the regulation of hemostasis and thrombosis. Previous studies have indicated that platelets generate contractile forces through actin-myosin interactions that lead to clot retraction and stability. If platelets are unable to generate forces, then the clots they form are loosely-bound and may detach to cause an embolism. Likewise, a higher propensity toward contractility by platelets may cause excessive clot formation in arteries and block blood flow.

Copyright © 2010 by ASME
Topics: Force , Platelets

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