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Alkanethiol Self-Assembled Monolayers on Microcantilever Biosensor

[+] Author Affiliations
Chia-Ching Chou, Shu-Wei Chang, Chuin-Shan Chen

National Taiwan University, Taipei, Taiwan

Paper No. NEMB2010-13214, pp. 41-42; 2 pages
doi:10.1115/NEMB2010-13214
From:
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • Houston, Texas, USA, February 7–10, 2010
  • Conference Sponsors: ASME Nanotechnology Council
  • ISBN: 978-0-7918-4392-5 | eISBN: 978-0-7918-3866-2
  • Copyright © 2010 by ASME

abstract

Microcantilever-based biosensors are rapidly becoming an enabling sensing technology for a variety of label-free biological applications due to their wide applicability, versatility and low cost. It is thus imperative for us to reveal the physical origin of adsorption-induced deformation, and to further analyze its implication of microscopic mechanisms on macroscopic deformation. In the paper, we study adsorption-induced surface stresses and microcantilever motion in alkanethiolate SAMs on Au surface. We develop a multiscale method that can analyze deformation of micro-cantilever beam subjected to bio-adsorption mechanisms calculated by ab-initio simulation and classical molecular dynamics. The adsorption mechanisms of different SAMs adsorbed on Au(111) surface, in the dry and liquid phase, are studied by ab-initio simulation and the adsorption-induced stresses are calculated through the multiscale method. The results give insight into the atomic forces and positions that play a key role in producing adsorption-induced surface stresses and resultant mechanical bending of microcantilevers.

Copyright © 2010 by ASME

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