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Aptamer-Based Lab-on-Chip for Cancer Cell Isolation and Detection

[+] Author Affiliations
Yuan Wan, Young-tae Kim, Samir M. Iqbal

University of Texas at Arlington, Arlington, TX

Li Na, Andrew D. Ellington

University of Texas at Austin, Austin, TX

Paper No. NEMB2010-13195, pp. 35-36; 2 pages
doi:10.1115/NEMB2010-13195
From:
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
  • Houston, Texas, USA, February 7–10, 2010
  • Conference Sponsors: ASME Nanotechnology Council
  • ISBN: 978-0-7918-4392-5 | eISBN: 978-0-7918-3866-2
  • Copyright © 2010 by ASME

abstract

The isolation and detection of circulating tumor cells (CTCs), when these are few in number or small in mass, can enable early cancer detection [1]. Currently, most research endeavors to isolate circulating tumor cells rely on antibodies and immunohistochemistry [2,3]. Aptamer are alternative molecules that have affinities and specificities that are comparable to those of antibodies [4,5], but these can be more readily adapted to many applications [6–9], including lab-on-a-chip devices. Here, we report use of a novel epidermal growth factor receptor (EGFR) aptamer biochip to identify and isolate cancer cells that overexpress EGFR. These results provide a solid basis for the development of diagnostic devices that can readily identify and isolate CTCs.

Copyright © 2010 by ASME
Topics: Cancer

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